Medvedev and Facundo Bagnis, 103rd in the world ranking, faced each other in the men’s singles first round match in the morning session of the 3rd day of the tournament held in the capital, Paris.
Medvedev, whose best score in Roland Garros was in the quarter finals, won 3-0 with 6-2 sets.
World number 40 Holger Rune scored an unexpected result by eliminating Denis Shapovalov (seeded 14) 3-0 (6-3, 6-1, 7-6) in the first round.
In women’s women, Karolina Pliskova (8), 141st place in the world Tessah Andrianjafitrimo 2-1 (2-6, 6-3, 6-1), Danielle Collins (9) defeated Viktoriya Tomova in the 140th place of the classification 2-0 ( 6-0, 6-4) to get a 2nd round ticket.
The 2017 champions Jelena Ostapenko (13) and Elena Rybakina (16) also continued on their way by overtaking their opponents.