For a long time, a psychological condition, the last tests show a biological origin
Chronic tired syndrome It is a form of severe and disabling asthenia, long -lasting that does not appear caused by a physical or psychological condition. Call too Encephalomielite myalgical It is a disorder that involves a persistent and inexplicable sense of fatigue, difficult to relieve. A recent study has identified some indications of a possible genetic origin of the disorder.
Chronic fatigue clues to a genetic origin
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The research was conducted by the GWAS, a genomic association, led byUniversity of Edinburgh and involved about 15,500 people. The results, published on Science, They showed that the genetic signals of chronic tired syndrome are placed near the areas involved in immune and neurological responses. THE’encephalomyelitis myalgic is often diagnosed following an infectionit seems to have symptoms in common with some viral diseases such as the condition of the Long Covid. There is no clinical test to diagnose chronic tired syndrome and mostly we try to exclude other pathologies that could have similar symptoms.
the disorder
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In Italy it is estimated that between 200 thousand and 300 thousand people suffer from chronic tired syndrome, they are mainly women between 40 and 50 years old. The identification of genetic bonds could allow to improve both the diagnoses and the identification of therapeutic paths to face chronic tired syndrome. The results of this study, which represents the largest analysis ever done on myalgic Encephalomyelitis, are still temporary and not subject to a equal review, but have allowed us to overcome the idea that it was only a psychological problem.
The results of the research on chronic fatigue
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The research was carried out by comparing the genetic data of patients with those of 260 thousand other people, who did not suffer from syndrome, whose data were present in the Biobank UK. The comparison made it possible to identify these genes that would be connected to chronic fatigue. Among these:
- Olfm4 which codes a protein involved in antimicrobial responses;
- C10 which is linked to chronic pain;
- Znfx1 associated with the response to RNA viruses;
- Rabgap1l Which seems to have a possible role in immune responses and which is identified as one of the potential triggering factors.
In addition, the researchers having noticed that most of these genes involved are active in the brain, have suggested an involvement of the nervous system as well as the immune one in chronic fatigue syndrome.
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