The association will first play on relocation on 6 March, a week later the return in Bruges follows.
Cercle Brugge insured himself with an eighth place in the League Phase of direct qualification for the eighth finals.
Jagiellonia finished ninth in the rankings and easily dealt with the Serbian TSC Backa Topola in the intermediate round.
If Cercle survives the eighth finals, the Spanish Real Betis or the Portuguese Vitoria de Guimaraes will wait in the quarterfinals. Bétis qualified against AA Gent last night, but it lost the return match with 0-1.