In this new in-depth analysis, Medikea’s column for Gazzetta Active dedicated to the science of healthy aging presents the results of a study published in Nature Medicine and the expert’s commentary

Sofia Vitali

January 15th – 5.15pm – MILAN

There are no miracle pills to live longer, but they exist daily choices which concretely increase the chances of aging healthily. This is confirmed a study published in 2025 on Nature Medicineone of the most authoritative scientific magazines in the world, which analyzed the link between nutrition, lifestyle and longevity. It is the theme of the in-depth analysis carried out by Medikea For Active Journal. Researchers followed tens of thousands of people for years, assessing not only how many years they lived, but how they reached old age. The goal was not simple survival, but what scientists define as healthy aging: reach 70–75 years of age while maintaining good physical, cognitive and emotional conditions, without serious chronic diseases. The result is clear: those who follow a balanced diet, rich in plant foods and consistent with the Mediterranean modelis much more likely to age well than those who adopt extreme or discontinuous regimes.

What the Nature Medicine study really says

The study shows that it is not a single “fashionable” diet that makes the difference, but a sustainable eating pattern over time. Researchers have observed significant benefits in people who regularly consume vegetables, fruit, legumes, whole grains, olive oil and fish, with limited intake of sugars, ultra-processed foods and low-quality fats. However, no solid association emerges between longevity and rigid regimes such as intermittent fasting or the ketogenic diet, although these can improve some metabolic parameters in the short term. In other words, improving cholesterol or blood sugar does not automatically mean living longer or better. Longevity, the study concludes, is not built with drastic interventions but with coherent, daily and maintainable habits.

“The magic pill does not exist”

A message that is fully confirmed in the words of Professor Ennio Tasciotti, head of the laboratory Human Longevity Program of the IRCCS San Raffaele. “We don’t yet have the magic pill that can make everyone younger,” he explains. “We have a lot of research and many ideas, but if we talk about what we can really implement today to guarantee good aging, the levers are few and very concrete”. According to Tasciotti, there are three pillars of longevity: nutrition, movement and relationships. Everything else, for now, remains closer to myth than to medicine.

Nutrition: less extremism, more continuity

Professor Tasciotti highlights how some diets that are very popular today can have positive effects on specific health parameters. Intermittent fasting and the ketogenic diet, for example, can improve cholesterol and glycemic index in the short term. The problem is another: “A direct association between these diets and lengthening of life has never been demonstrated.” The only dietary model that, to date, shows a clear link with longevity remains the Mediterranean diet, also according to the data of the study published in Nature Medicine. The reason is simple: it is varied, balanced, socially sustainable and can be followed throughout your life, without metabolic stress or extreme sacrifices.

Movement: you don’t need to be super sporty

Science also debunks another widespread myth regarding physical activity. You don’t need to train like a professional athlete to live longer. “Indeed – underlines Tasciotti – excessive high intensity sport, especially at an advanced age, can sometimes be counterproductive. What matters is constant movement, adapted to age and physical conditions. An activity that combines aerobic exercises, useful for the heart and lungs, with strength and resistance exercises, which are especially fundamental after the age of 65, when muscle mass tends to reduce”. Walking, doing weight exercises, maintaining good mobility: This is the true “gym” of longevity.

Mediterranean diet first in the world for longevity and health

Relationships, mind and prevention: the invisible factor

The study of Nature Medicine and clinical experience converge on another often overlooked point: the quality of relationships and mental life has a profound impact on aging. Cognitive stimuli, active social relationships and emotional well-being help reduce the risk of cognitive decline and frailty. Added to this is prevention: many chronic diseases begin to develop 10 or 20 years before symptoms appear. “Being able to intercept them early makes treatments simpler and more effective,” underlines Tasciotti. For this reason, contacting your doctor and undergoing regular check-ups is a valid recommendation for everyone.

The true lesson of longevity

The message that emerges, from scientific study as from clinical practice, is as clear as it is unspectacular: shortcuts don’t work. Longevity is not a miraculous promise, but a path built over time. Eat in a balanced way, move regularly, cultivate relationships, take care of your health and your mind. Today, this is the only formula that science recognizes as truly effective for living longer and better.



ttn-14