Nohe doesn’t like to talk about “miracles”. And not even science fiction. The professor Carlo Tremolada he prefers to talk about biology, microvasculature, cells that communicate with each other and the human body’s innate ability to regenerate. But listening to him talk about what happens today in the operating rooms and laboratories that he manages between Italy and Switzerland, it is difficult not to have the feeling that something is really changing in regenerative medicine. “We do nothing but enormously enhance something that the body already has,” he explains during a long conversation that goes through plastic surgery, orthopaedics, menopause, oncology and exosome research. «The real revolution is this: not imposing something from the outside, but help the tissue regain its natural healing capacity». His new book will also be released in July, The body that regeneratespublished by Mondadori.
Fat not as filler, but as regenerative tissue
The heart of the technique developed by Tremolada starts from autologous adipose tissue, that is, the patient’s own fat. But this is not the classic aesthetic lipofilling. Scientific Director, specialist in plastic and reconstructive surgery, maxillofacial surgery and international reference in regenerative medicine and surgery, Professor Carlo Tremolada is also the inventor of Lipogems technology. «We are not talking about something experimental», underlines Tremolada. «There are over 250 scientific publications and more than 170 thousand cases treated in the world».
«The fundamental difference», he explains, «is that we we do not isolate stem cells. We do the opposite: we keep them in their vascular-stromal niche, that is, in their natural environment.” According to Tremolada, this is precisely the key point. «Isolated stem cells can have a anti-inflammatory effect, but then they tend to go away. Here, however, they remain where they are implantedthey take root and continue to work over time.” The adipose tissue is microfragmented into tiny particles, keeping the vascular and cellular network intact. «By reducing the fat into very small fragments we enormously increase the biologically active surface. Thus the tissue is better vascularized and survives better.”
«It’s like bringing the tissue back to healing like that of a child»
Tremolada often uses a precise image to explain the concept of regeneration. “What we see clinically is this: the tissue heals again like that of a child.” He doesn’t just talk about aesthetic medicine. Applications today concern joints, tendons, radiotherapy results, scars, damaged and atrophic tissues. “THE’anti-inflammatory effect is relatively rapid. But the real one regeneration takes time. It’s a real biological process.”
According to the professor, one of the most interesting aspects is precisely the duration of the effect. «The cells stay there because the tissue takes root. It’s not a temporary flare-up.”
Menopause and vaginal atrophy: «Here the quality of the tissue really changes»
One of the most surprising chapters of the conversation concerns gynecology and menopause. And it is probably the topic that most interests the female world. «We have published works onvaginal atrophy, on theincontinence and on pelvic floor problems“, tells. The treatment is carried out with local microinjections of the regenerative tissue. «What changes is not simply the appearance, but the biological quality of the tissue. Improve the vascularizationimproves the lubrication, it decreases the pain in relationships.”
According to Tremolada the change also concerns fsexual unity. “Many women report an increase in sensitivity and a significant improvement in their quality of life.” And he adds, with his direct style: «For me the point is not to do extreme or aesthetic things. The real revolution is function.”
Does your skin really change? «It’s not a filler»
Even in aesthetic medicine the professor insists on a precise distinction. «We are not talking about a classic filler. Here the biological quality of the tissue changes.” A portion of the microfragmented adipose tissue can be injected into the superficial dermis. «The skin changes radically over time: tone, quality, vascularization. But patience is neededbecause regeneration is not immediate.” During the interview, Tremolada shows us follow-up photographs years later. «What interests us is to see a fabric that continues to improve. We observe that it is almost an inverse process of aging.”
Exosomes, the next frontier of regenerative medicine
But for Professor Tremolada all this is already almost “past”. The new frontier, he says, are exosomes. «It’s the vesicles with which cells communicate with each other. It is probably one of the most interesting fields of regenerative medicine.” He also founded a new company in Switzerland dedicated to this sector. “The idea is to use these biological substances in an increasingly precise and less inflammatory way.”
The professor describes them as one of the most promising frontiers of regenerative medicine: tiny biological messengers capable of carrying molecular signals between cells and modulating inflammation, repair and tissue regeneration.
«The real idea», he explains, «is to be able to use more and more what the body already produces naturally, but in a more precise and less inflammatory way.” According to the professor, the future of regenerative medicine will increasingly move towards treatments capable of stimulating the body’s biological processes without “forcing” them. “We don’t impose something on the body,” he concludes. “We’re trying to allow him to do better what he’s already been able to do for millions of years.”
«True regenerative medicine does not force the body»
Throughout the conversation, the professor continually returns to a fundamental concept: not to fight the body, but to help it. «We are a living biochemical laboratory» he says at a certain point. “The most important thing is often not to disturb the natural mechanisms of the tissue.” And this is perhaps the most interesting part of his approach: a highly technological medicine that however continues to speak the language of natural biology. “We don’t invent anything,” he concludes. “We’re just trying to allow the body to do better what it has already been able to do for millions of years.”
Professor Carlo Tremolada
Scientific Director, Specialist in plastic and reconstructive surgery, maxillofacial surgery, and international reference in regenerative medicine and surgery. Inventor of Lipogems technology.
Plastic and Maxillofacial Surgeon, point of reference in aesthetic medicine and surgery. Professor Tremolada is a leading figure in Regenerative Medicine at an international level. As a researcher and creator of the Lipogems®️ patentthe most widely used regenerative medicine and surgery technique in the world, has published numerous articles on the use of stem cells. He is also the founder of LIPOGEMS®️, EXOGEMS and LIPOBANK. He has trained and continues to train generations of surgeons in the application and use of the most advanced techniques of regenerative medicine and surgery.
