Cognitive decline: the 2 common ingredients that would help to stop him

A tea and a vitamin could rejuvenate brain cells in less than a day. At least in the laboratory, where some Agested neurons returned “young” in 16 hours thanks to the combination of Nicotinamide (Vitamin B3) and EGCGthe antioxidant of green tea.

The secret, according to a group of American researchers, lies in the GTP, the energy molecule That, by aging, brain cells produce less and less. Without it, neurons struggle to eliminate damaged proteins and debris that accumulate by disturbing brain functions. The study of the University of California of Irvine, published on Geroscienceshows that aged brain cells, including those with symptoms similar to Alzheimer’s, have restored their GTP levels after a single treatment. The tea and vitamin B3 combination has also eliminated accumulations of toxic proteins related to the disease and improved cell survival by 22%.

Ingredients against the decline: the study

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Gregory Brewer And colleagues have isolated neurons from healthy and genetically modified mice to develop symptoms similar to the Alzheimer of three age groups: young people (2-6 months), middle-aged (8-11 months) and the elderly (17-28 months). Using a fluorescent sensor called Geval, the researchers measured the GTP levels in real time inside the neurons, then treating the oldest ones with Nicotinamide, EGCG, or both together for 16 hours. The discovery was that energy levels followed different trajectories according to age and disease. In healthy neurons, the GTP increased in the middle age and then dropped into old age. In those of the Alzheimer model, the decline began before and remained low. After 16 hours of combined treatment, the neurons of both groups have regained GTP levels comparable to those of young cells.

Energy restoration had visible effects: The neurons have started to eliminate cell waste again, including the accumulations of amyloid-ceta protein often present in the Alzheimer. The treatment also reduced the accumulation of vesicles involved in the waste processing, which tend to accumulate in aged neurons when energy is scarce. How is it possible?

Nad and metabolism

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In practice, scientists, which Nicotinamide increases the levels of Nad+, a molecule that supports cellular metabolism and serves as a precursor in the production of GTP. The EGCG instead activates NRF2, a cell defense switch that lights protective antioxidant genes. Two fundamental mechanisms for the body.

However, the experiment has some limits: it was conducted on Petri plates neuronsnot in live animals, and measured only short -term effects. And there was no experimentation on humans (for now). So it is not known if the benefits would persist over time. But a good in vitro result is always an excellent motivator for science.