THEendometriosis In Italy it affects 3 million women. It is a disabling disease that causes Pelvic pains, very painful menstruation, gastrointestinal and urinary disorders and a reduction in fertility in about 40% of the severe cases. To shed light on this pathology, in recent years scientific studies have opened the way to the involvement of the microbiota in the pathogenesis of endometriosis. Just to investigate the link between endometriosis and microbiota will start A new study that will involve 2000 women aged 18 and over. Experts explain it.
Endometriosis and microbiota: what link
It has been shown that The microbiota plays a role both in the immunity of the guest and in the metabolism of estrogen. And the endometriosis is, in all respects, a pathology dependent on the estrogen in which it coexists an discomfort of the immune system. The study Biome-end, In collaboration with Wellmicrowill be conducted by the complex operating unit of gynecology and obstetrics ofIRCCS Sacro Cuore Hospital Don Calabria of Negrar of Valpolicella di Verona. The goal is Compare the vaginal, cervical and rectal microbioma in patients with endometriosis In various locations (ovarian, peritoneal, deep endometriosis) and in patients without endometriosis. This will allow to tie the evaluation of the microbiota of the three different vaginal districts to the severity of the endometriosis pathology. The microbiota will thus become an important element of the prognostic definition of the disease and help in defining which patients will be able to present greater or lesser symptoms and postoperative complications.
The main symptoms
“Endometriosis is characterized by the presence of cells similar to endometrial tissue outside the uterine cavity in ectopic offices, such as peritoneum, ovaries, fallopian tube, intestine, bladder. The main symptom of this disease is painmainly During menstruationi sexual intercoursethe defecationthe urination or even outside the menstrual period. The disease can also be completely asymptomatic, in serious cases leading to the compromise of some organs such as kidney and intestine “, explains the Doctor Marcello Ceccaroni, Director of the Department for the protection of health and quality of life of the UOC Woman of Obstetrics and Gynecology, ISSA President – International School of Surgical Anatomy IRCCS Sacro Hospital – Heart Don Calabria Negrar of Valpolicella, Verona.
Microbiota and health
«The intestinal microbioma, with its 3,300,000 genes, is the powerful director of our health, together with the intestine and the visceral brain. It constantly dialogues with the microbioma of the other body districts, including the vaginal, bladder, endometrial microbioma. The microbioma In dynamic balance protects our health. If altered it becomes in turn co-facators and accelerator of different pathologiesespecially in case of persistent dysbiosis. Preliminary data suggest that the ingiotic microbioma in its different districts can also accelerate the progression of the endometriosis and worsen the pain.
That’s why I enthusiastically participate in this pioneering study, full of implications to help women affected by endometriosis in an increasingly effective and innovative way “, says the professor Alessandra Graziottin, Professor AC at the Department of Obstetrics and Gynecology ofUniversity of VeronaDirector of the center of gynecology and medical sexology H.SAN Raffaele Resnati of Milan and president of the Graziottin Foundation for the treatment of pain in the Onlus woman.
I woman © RESERVED REPRODUCTION