NON is a crusade against frying or an attack on habits in the kitchen: one New search for the Weill Cornell Medicine in New York lights the spotlight on a widespread substance in our daily diet, Linoleic acid, present above all in various types of seed oil. According to the study, this molecule could have a role in the growth of negative triple breast cancera particularly aggressive and difficult form to treat. No alarmism, but a discovery that offers new reading keys on how nutrition can influence health, and opens the path to more aware nutritional strategies.
Seed oil, linoleic acid and breast cancer: the bond
The research published on Science has studied Linoleic acid, a Omega-6 fat present in oils such as soy and sunflower and foods such as pork and eggscan influence the “Mtorc1 route”that switch that regulates cell growth. Scientists, led by Professor John Blenis, found that Linoleic acid is capable of “turning” this switchbut only in the cells of the negative triple breast cancer, both in the laboratory and in animals.
This happens because Linoleic acid is Leg to a protein called Fabp5. It is as if the latter took Linoleic acid and bring it to the Mtorc1 switch, activating it and thus pushing the cancer cells to grow.
A possible indicator for personalized therapies
An important result is the role of the fabp5 protein. The researchers found high levels of this protein both in animals with triple negative cancer and in the samples of patients just diagnosed. This suggests that It could be a “biomarcator”, that is, a signal indicating the presence of the disease And that could help doctors understand which patients could benefit from specific therapies and food advice. Professor Blenis said: «This discovery there It helps to better understand the link between the fats we eat and the cancerand to identify patients who could have more benefits from Personalized nutritional recommendations».
Negative triple breast cancer: because it is difficult to cure
The “negative triple” breast cancer It is a particular form in which the cancer cells do not express three specific receptors On their surface: the estrogen receptor (ER), the progesterone receptor (PR) and the type 2 human epidermal growth receptor (Her2). This triple negativity is the reason for its name. There Difficulty in treatment derives precisely from the absence of these receptors, which In other types of breast cancer they represent specific “targets” for hormonal therapies or targeted drugs. As a result, the therapeutic options for negative triple are often more limited and mainly include chemo and radiotherapy.
Seed oil, omega-6 and diet: moderation for breast health
Linoleic acid, despite being an essential nutrient, is widely present in the western dietin particular due to the incarmented Use of seed oils in the food industry. This abundance generated questions about the potential impact of an excessive hiring of Omega-6 on health, including the possible correlation with the incidence of some forms of breast cancer.
However, the authors of the study underline the importance of moderation. As Professor Blenis said, “The results do not justify an absolute refusal of seed oils, but suggest moderation and selectivityespecially for high risk individuals ». The balance between Omega-6 and Omega-3 in the diet remains fundamental. As always, the usual known ones return to the top of the list: fruit, vegetables and varieties.
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